The classic love triangle formula gives us one good woman and one bad woman The Schuyler sisters follow that love triangle formula closely, right up until they don’t. Part of the reason for this confusion - is the musical making a feminist statement? Being horrifically regressive? Are the Schuyler sisters boring? Are they fascinating? - is that their story arc has the structure of a very old and not very feminist musical theater trope: the two-woman love triangle in which one woman is good and the other is bad. Two Gay Matts) opine that "this show is all about the bitches." New York magazine insists that the show’s treatment of its women "invites questions." The New York Times says, "We love, but love, the assertive revolutionary women." Elsewhere in the New Yorker, Hilton Als writes that the Schuyler sisters are the weakest part of the show, calling them "plot points in silk," while YouTube critics Matt Steele and Matt Palmer (a.k.a. In the Wall Street Journal, Peggy Noonan is happy to announce that the Schuyler sisters are "not politically correct" because they are not "forced to adopt the usual modern scattershot bitterness at their plight." In a New Yorker article on the women of Hamilton, Michael Shulman approvingly calls the Schuyler sisters "almost" feminist. No one can quite decide what Hamilton is doing with the Schuyler sisters. And at the play’s conclusion, a somber Aaron Burr sings, "They say Angelica and Eliza were both at his side when he died." Throughout the rest of the show the Schuyler sisters weave in and out of Hamilton’s life, reminding him of the world that exists outside of the policy he’s writing. The sisters meet young Hamilton early in Act I and are both instantly smitten, but perceptive, quick-thinking Angelica decides to encourage Hamilton to pursue sweet, kind Eliza rather than go after him herself.
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Main applications are optimization of the dosage and study of skin transport.
Experimental data of transdermal melatonin allow validation. organs/tissues) via material balances on homogeneous compartments. The combined model accounts for skin transport via diffusion equations, and absorption and distribution in the rest of the body (i.e. The skin model features three strata: stratum corneum, viable epidermis, and dermis, which have a major impact on the absorption, distribution, and metabolism of transdermal drugs. This is achieved by an innovative combination of the physiologically-based compartmental approach with Fick’s laws of diffusion. This paper proposes a model for the study and prediction of drug transport through skin and the following distribution to human body. ABSTRACT: There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages: non-invasive procedure, pain avoidance, no first-pass hepatic metabolism, and induction of sustained plasma levels.